A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney injury
نویسندگان
چکیده
Abstract Acute kidney injury (AKI) exhibits high morbidity and mortality. Kidney molecule-1 (KIM1) is dramatically upregulated in renal tubules upon injury, acts as a biomarker for various diseases. However, the exact role underlying mechanism of KIM1 progression AKI remain elusive. Herein, we report that tubular specific knockout Kim1 attenuates cisplatin- or ischemia/reperfusion-induced male mice. Mechanistically, transcription factor Yin Yang 1 (YY1), which downregulated AKI, binds to promoter represses its expression. Injury-induced ECD domain death receptor 5 (DR5), activates DR5 following caspase cascade by promoting multimerization, thus induces cell apoptosis exacerbates AKI. Blocking KIM1-DR5 interaction with rationally designed peptides exhibit reno-protective effects against Here, reveal YY1-KIM1-DR5 axis warrants future exploration therapeutic targets.
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2023
ISSN: ['2041-1723']
DOI: https://doi.org/10.1038/s41467-023-40036-z